Combigan Eye Drop 5ml

Active Ingredients & Composition

Each ml of the ophthalmic solution contains a combination of two pressure-lowering agents: 

• Brimonidine Tartrate IP (2 mg / 0.2% w/v): An alpha-2 adrenergic receptor agonist that decreases fluid production and simultaneously enhances alternative drainage (uveoscleral outflow) from the eye. 
• Timolol Maleate IP (equivalent to Timolol 5 mg / 0.5% w/v): A non-selective beta-adrenergic receptor blocker that lowers internal eye pressure by significantly reducing the formation of aqueous humor (fluid) inside the ciliary body. 
• Benzalkonium Chloride IP (0.05 mg): Serves as the primary antimicrobial preservative. 
• Purified Water IP: q.s. (quantity sufficient). 

Combigan Ophthalmic Solution (5 ml) – Product Description

Key Benefits

• Dual-Action Pressure Control: Merges a beta-blocker and an alpha-agonist to target pressure from two biological pathways.
• Optic Nerve Protection: Rapidly lowers intraocular pressure (IOP) to stall or prevent glaucoma progression.
• Optimized Fluid Dynamics: Decreases overall internal eye fluid production while actively stimulating alternative outflow drainage channels.
• Sustained Efficacy: Formulated to maintain stable pressure regulation throughout the day under a doctor's standard dosing regimen. 

Directions for Use

1. Clean your hands comprehensively before opening the container.
2. Tilt your head backward, look upward toward the ceiling, and pull down your lower eyelid to generate a pocket.
3. Invert the dropper bottle and squeeze a single drop into the eye pocket as directed by your physician.
4. Close your eye gently and press the inner corner of your eye (near the nose) with a clean finger for 1 to 2 minutes to minimize systemic absorption into the bloodstream.
5. If wearing contact lenses: Always remove them prior to administering Combigan and wait at least 15 minutes before reinserting.
6. Keep the dropper tip clear of any surface contact (including your eye or hands) to shield the bottle from bacterial contamination. [1]

Critical Safety Warnings & Precautions

• Prescription Only (Rx): This medication must only be used under the strict supervision of an ophthalmologist or qualified eye specialist. 
• Systemic Side Effects: Because it contains a beta-blocker (Timolol), this medication can be absorbed systemically and is strictly contraindicated in individuals with a history of asthma, chronic obstructive pulmonary disease (COPD), or severe cardiac conditions (such as sinus bradycardia or heart block). 
• Temporary Vision Shifts: Mild stinging, burning, or blurred vision may manifest immediately after application. Avoid driving or operating machinery until your vision is entirely clear. 
• Co-Administration Rule: If using other topical ophthalmic products, separate application times by a minimum interval of 10 minutes to prevent drug washout.
• Age Limitation: This formulation is strictly not for use in infants or children under 2 years of age due to potential central nervous system depression risks.
• Storage Protocol: Store at a controlled room temperature away from freezing and intense heat. Keep out of reach of children and discard the bottle 4 weeks after opening.

 Medical Disclaimer

The information outlined above is intended strictly for consumer educational purposes and must not replace professional clinical advice, medical diagnosis, or treatment. Always consult your ophthalmologist regarding personal medical conditions, severe eye pain, changes in vision, or persistent eye inflammation.